Enzyme Cleaner Market Report: Sales Volume, Market Share, Leading Brands & Market Trends
Enzyme Cleaner sales on Amazon US totaled 577,900 units in July 2026 (▲ 6.2% vs. the prior month), generating an estimated $10,135,919 in revenue across the 50 top-ranked ASINs for this search term. Demand is heavily concentrated at the top of the ranking — the ten best performers capture 64.0% of unit volume and 52.3% of revenue, while a typical listing is priced at $23.10. The keyword itself pulled 127,871 Amazon queries over the same period (▲ 35.0% MoM).
Zooming out to the 12-month window ending July 2026, the enzyme cleaner Top 50 moved 4,938,750 units and $88,029,608 in cumulative sales — an average of 411,563 units and $7,335,801 per month. Monthly throughput topped out at 577,900 units in July 2026 and dipped to 269,300 in May 2026, leaving the latest reading 58.6% higher than August 2025.
Enzyme Cleaner Sales Trend (Trailing 12 Months)
Based on the top 50 ASINs by monthly sales for this keyword
2025/08
2025/09
2025/10
2025/11
2025/12
2026/01
2026/02
2026/03
2026/04
2026/05
2026/06
2026/07
Monthly Sales 2026/07
577.9K
▲ 6.2% MoM
Monthly Revenue 2026/07
$10.1M
▲ 5.5% MoM
Top 10 Market Share 2026/07
64.0%
Enzyme Cleaner Market Share & Sales Concentration on Amazon US — July 2026
The most-sold enzyme cleaner listing on Amazon US in July 2026 is ASIN B000VDX2SS (Brand: SHOUT), which sold 100,000 units at $3.48 apiece — equal to 17.3% of every unit tracked in this report and 1.7× the volume of the No. 2 listing.
The Top 10 ASINs account for 370,000 units and $5,305,600 in July 2026 — 64.0% of unit volume and 52.3% of revenue among all 50 ranked ASINs in this report.
Sales Volume of Top ASINs for 'Enzyme Cleaner' on Amazon
July 2026









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Top 5 Volume Share breakdown

B000VDX2SS
SHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz
100K
▲ 25.0%vs. prior month
$335K
latest month
12-month trend

B00CKFL93K
Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars
60K
▲ 20.0%vs. prior month
$1.4M
latest month
12-month trend

B0CJH9DRM6
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
50K
▲ 0.0%vs. prior month
$942K
latest month
12-month trend

B0FK7K482H
ACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply
30K
▲ 0.0%vs. prior month
$749.4K
latest month
12-month trend

B0BGQSD3PJ
Drano Max FlowGuard Build-Up Remover, Probiotic Enzyme Drain Cleaner, 60 oz | Probiotic enzyme formula helps prevent clogs and remove odors and buildup; safe for pipes, septic systems, sinks and toilets
30K
▲ 0.0%vs. prior month
$351K
latest month
12-month trend

B09KQTY9YR
Nature's Miracle Cat Urine Destroyer Plus, Enzymatic Cleaner, 32 oz | Destroys the Toughest Cat Urine Stains, For Use on Multiple Surfaces, Safe For Pets and Home*, Fresh Scent
20K
▲ 0.0%vs. prior month
$254.4K
latest month
12-month trend
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Best Enzyme Cleaner Brands on Amazon US — Top 3 Brand Sales Concentration (July 2026)
SHOUT is the best-performing enzyme cleaner brand in July 2026, moving 100,000 units across 1 ASIN for 27.0% of Top 10 volume. ACTIVE follows with 80,000 units (21.6%), ahead of Rocco & Roxie Supply Co. on 60,000 units (16.2%).
With 7 brands splitting the Top 10 and 64.9% of volume sitting with three of them, this is a concentrated shelf — the leaders hold multiple listings or one very high-velocity ASIN, so a new entrant competes against established review moats rather than an open field. Average selling prices among the leaders run from $3.48 to $23.92, which frames the price band a competing listing has to justify.
Brand share of Top 10 volume
SHOUT
1 ASIN in Top 10
27.0%
Units
100K
Revenue
$335K
Avg. price
$3.48

B000VDX2SS
$3.48·★4.7·19.1K revsSHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz
Units sold100K
ACTIVE
2 ASINs in Top 10
21.6%
Units
80K
Revenue
$1.7M
Avg. price
$22.95

B0CJH9DRM6
$19.95·★4.6·7.3K revsEnzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
Units sold50K
B0FK7K482H
$25.95·★4.6·3.6K revsACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply
Units sold30K
Rocco & Roxie Supply Co.
1 ASIN in Top 10
16.2%
Units
60K
Revenue
$1.4M
Avg. price
$23.92

B00CKFL93K
$23.92·★4.4·127.4K revsRocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars
Units sold60K
Trending Enzyme Cleaner Products — Growth Leaders & New Top 10 Entrants
Based on July 2026 data, this shortlist surfaces the two kinds of ASIN worth keeping an eye on — the ones that just broke into the Top 10, and the ones growing fastest month over month. Specifically, one ASIN forced its way in: B09KQVCC67 booked 20K units at $12.72, with ▲ 100.0% MoM change. On the growth side, B0717BLT6V leads positive momentum with ▲ 275.0% MoM growth on 3K units, with B005P0UYDS close behind at ▲ 100.0% MoM on 6K units.
The two signals carry different weight. A fresh entrant means share has already changed hands — an incumbent gave up its place to make room, so any competitive set drawn up a month ago is now out of date. A steep growth rate works as the earlier warning: it marks demand that is still compounding, usually a month or two before the ranking catches up to it.

B09KQVCC67
Nature's Miracle Dog Urine Destroyer Plus, Enzymatic Cleaner, 32 oz | Destroys the Toughest Dog Urine Stains, For Use on Multiple Surfaces, Safe For Pets and Home*, Fresh Scent
Price
$12.72
Rating
4.5
Reviews
4.5K
Latest month sales

B0717BLT6V
Nature’s Miracle Dog Stain & Odor Remover, Enzymatic Cleaner, 24 oz | Tough on Dog Urine, Feces, Vomit, Drool and Other Organic Stains and Odors, For Multiple Surfaces, Fresh Scent
Price
$8.97
Rating
4.6
Reviews
23.5K
Latest month sales

B005P0UYDS
Biokleen Bac-Out Enzyme Cleaner Spray and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 32 Ounces
Unlock to view ASIN details and product titles
Price
$12.73
Rating
4.5
Reviews
3.2K
Latest month sales
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