Enzyme Cleaner Market Report: Sales Volume, Market Share, Leading Brands & Market Trends

July 2026

Enzyme Cleaner sales on Amazon US totaled 577,900 units in July 2026 (▲ 6.2% vs. the prior month), generating an estimated $10,135,919 in revenue across the 50 top-ranked ASINs for this search term. Demand is heavily concentrated at the top of the ranking — the ten best performers capture 64.0% of unit volume and 52.3% of revenue, while a typical listing is priced at $23.10. The keyword itself pulled 127,871 Amazon queries over the same period (▲ 35.0% MoM).

Zooming out to the 12-month window ending July 2026, the enzyme cleaner Top 50 moved 4,938,750 units and $88,029,608 in cumulative sales — an average of 411,563 units and $7,335,801 per month. Monthly throughput topped out at 577,900 units in July 2026 and dipped to 269,300 in May 2026, leaving the latest reading 58.6% higher than August 2025.

4.9MTotal units sold · Last 12 months
$88MTotal revenue · Last 12 months
127.9K▲ 35.0% MoM
Monthly search volume
$23.10Avg. price · July 2026

Enzyme Cleaner Sales Trend (Trailing 12 Months)

Based on the top 50 ASINs by monthly sales for this keyword

Sales
Revenue

2025/08

Sales364.3K
Revenue$6.4M

2025/09

Sales369.6K
Revenue$6.6M

2025/10

Sales392.8K
Revenue$6.9M

2025/11

Sales417K
Revenue$7.2M

2025/12

Sales289.2K
Revenue$5.3M

2026/01

Sales358.9K
Revenue$6.3M

2026/02

Sales428.6K
Revenue$7.7M

2026/03

Sales457.6K
Revenue$8.3M

2026/04

Sales469.2K
Revenue$8.7M

2026/05

Sales269.3K
Revenue$4.8M

2026/06

Sales544.4K
Revenue$9.6M
577.9K

2026/07

Sales577.9K
Revenue$10.1M
25/0925/1126/0126/0326/0526/07
ASINSIGHT
Source: www.asinsight.com

Monthly Sales 2026/07

577.9K

▲ 6.2% MoM

Monthly Revenue 2026/07

$10.1M

▲ 5.5% MoM

Top 10 Market Share 2026/07

64.0%

See the Top 10 ASINs driving 64.0% of sales

Enzyme Cleaner Market Share & Sales Concentration on Amazon US — July 2026

The most-sold enzyme cleaner listing on Amazon US in July 2026 is ASIN B000VDX2SS (Brand: SHOUT), which sold 100,000 units at $3.48 apiece — equal to 17.3% of every unit tracked in this report and 1.7× the volume of the No. 2 listing.

The Top 10 ASINs account for 370,000 units and $5,305,600 in July 2026 — 64.0% of unit volume and 52.3% of revenue among all 50 ranked ASINs in this report.

Sales Volume of Top ASINs for 'Enzyme Cleaner' on Amazon

July 2026
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64.0% Volume Share 370K units sold
52.3% Revenue Share $5.3M estimated
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Top 5 Volume Share breakdown

B000VDX2SS 17.3%
B00CKFL93K 10.4%
B0CJH9DRM6 8.7%
B0FK7K482H 5.2%
B0BGQSD3PJ 5.2%
Others 53.3%
#1
SHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

B000VDX2SS

SHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

$3.48· 4.7·19.1K reviews
Monthly Sales

100K

▲ 25.0%

vs. prior month

Revenue

$335K

latest month

Monthly Trend

12-month trend

#2
Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars

B00CKFL93K

Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars

$23.92· 4.4·127.4K reviews
Monthly Sales

60K

▲ 20.0%

vs. prior month

Revenue

$1.4M

latest month

Monthly Trend

12-month trend

#3
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

B0CJH9DRM6

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

$19.95· 4.6·7.3K reviews
Monthly Sales

50K

▲ 0.0%

vs. prior month

Revenue

$942K

latest month

Monthly Trend

12-month trend

#4
ACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply

B0FK7K482H

ACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply

$25.95· 4.6·3.6K reviews
Monthly Sales

30K

▲ 0.0%

vs. prior month

Revenue

$749.4K

latest month

Monthly Trend

12-month trend

#5
Drano Max FlowGuard Build-Up Remover, Probiotic Enzyme Drain Cleaner, 60 oz | Probiotic enzyme formula helps prevent clogs and remove odors and buildup; safe for pipes, septic systems, sinks and toilets

B0BGQSD3PJ

Drano Max FlowGuard Build-Up Remover, Probiotic Enzyme Drain Cleaner, 60 oz | Probiotic enzyme formula helps prevent clogs and remove odors and buildup; safe for pipes, septic systems, sinks and toilets

$14.05· 4.0·5K reviews
Monthly Sales

30K

▲ 0.0%

vs. prior month

Revenue

$351K

latest month

Monthly Trend

12-month trend

#6
Nature's Miracle Cat Urine Destroyer Plus, Enzymatic Cleaner, 32 oz | Destroys the Toughest Cat Urine Stains, For Use on Multiple Surfaces, Safe For Pets and Home*, Fresh Scent

B09KQTY9YR

Nature's Miracle Cat Urine Destroyer Plus, Enzymatic Cleaner, 32 oz | Destroys the Toughest Cat Urine Stains, For Use on Multiple Surfaces, Safe For Pets and Home*, Fresh Scent

$12.72· 4.5·7.1K reviews
Monthly Sales

20K

▲ 0.0%

vs. prior month

Revenue

$254.4K

latest month

Monthly Trend

12-month trend

Unlock to view all Top 50 ASIN competitors and their sales contributions

Best Enzyme Cleaner Brands on Amazon US — Top 3 Brand Sales Concentration (July 2026)

SHOUT is the best-performing enzyme cleaner brand in July 2026, moving 100,000 units across 1 ASIN for 27.0% of Top 10 volume. ACTIVE follows with 80,000 units (21.6%), ahead of Rocco & Roxie Supply Co. on 60,000 units (16.2%).

With 7 brands splitting the Top 10 and 64.9% of volume sitting with three of them, this is a concentrated shelf — the leaders hold multiple listings or one very high-velocity ASIN, so a new entrant competes against established review moats rather than an open field. Average selling prices among the leaders run from $3.48 to $23.92, which frames the price band a competing listing has to justify.

Brand share of Top 10 volume

27.0%
21.6%
16.2%
35.1%
SHOUT
ACTIVE
Rocco & Roxie Supply Co.
Other brands
1

SHOUT

1 ASIN in Top 10

27.0%

Units

100K

Revenue

$335K

Avg. price

$3.48

  • SHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

    B000VDX2SS

    $3.48·4.7·19.1K revs

    SHOUT Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

    Units sold100K
2

ACTIVE

2 ASINs in Top 10

21.6%

Units

80K

Revenue

$1.7M

Avg. price

$22.95

  • Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

    B0CJH9DRM6

    $19.95·4.6·7.3K revs

    Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

    Units sold50K
  • ACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply

    B0FK7K482H

    $25.95·4.6·3.6K revs

    ACTIVE Washing Machine Cleaner for Pet Owners Enzymatic Deep Clean Descaler for Cat & Dog Hair, Urine, Odor, Residue, 24 Septic-Safe Tablets for Top Load, Front Loader, HE Washer Tub - 1 Year Supply

    Units sold30K
3

Rocco & Roxie Supply Co.

1 ASIN in Top 10

16.2%

Units

60K

Revenue

$1.4M

Avg. price

$23.92

  • Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars

    B00CKFL93K

    $23.92·4.4·127.4K revs

    Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz | Bio-enzymatic urine destroyer; CRI Certified Safe; made in USA; for carpets, bedding, litter boxes, crates & cars

    Units sold60K

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